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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPS6KB1
All Species:
23.94
Human Site:
S441
Identified Species:
37.62
UniProt:
P23443
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23443
NP_003152.1
525
59140
S441
S
P
R
R
F
I
G
S
P
R
T
P
V
S
P
Chimpanzee
Pan troglodytes
XP_523815
451
50966
K370
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
Rhesus Macaque
Macaca mulatta
XP_001109701
525
59511
S441
S
P
R
R
F
I
G
S
P
R
T
P
V
S
P
Dog
Lupus familis
XP_537702
525
59107
S441
S
P
R
R
F
I
G
S
P
R
T
P
V
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8BSK8
525
59199
S441
S
P
R
R
F
I
G
S
P
R
T
P
V
S
P
Rat
Rattus norvegicus
P67999
525
59113
S441
S
P
R
R
F
I
G
S
P
R
T
P
V
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509850
482
54026
S398
S
P
R
R
F
I
G
S
P
R
T
P
V
S
P
Chicken
Gallus gallus
P18652
752
84421
N428
V
Q
Q
L
H
G
K
N
I
Q
F
S
D
G
Y
Frog
Xenopus laevis
P10666
629
71268
N409
V
P
K
T
H
S
K
N
V
L
F
T
D
V
Y
Zebra Danio
Brachydanio rerio
Q6PFQ0
740
83378
Y431
E
D
I
G
V
G
S
Y
S
I
C
K
R
C
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3I5
1207
137026
L1094
T
H
R
V
V
R
T
L
P
P
T
F
G
T
T
Honey Bee
Apis mellifera
XP_395876
456
51514
A374
S
A
P
I
D
S
P
A
E
Y
T
L
S
E
S
Nematode Worm
Caenorhab. elegans
Q21734
784
88102
T451
T
A
K
T
N
P
F
T
D
D
Y
E
I
L
E
Sea Urchin
Strong. purpuratus
XP_781234
487
53968
H404
P
S
V
L
E
S
M
H
Q
K
V
H
H
F
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39030
471
53019
I389
G
P
S
G
A
E
E
I
K
K
H
K
W
F
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.9
94.2
99.8
N.A.
99.2
99.6
N.A.
90.2
31.9
36.8
32.2
N.A.
20.8
54.6
31.2
59
Protein Similarity:
100
85.9
95.6
100
N.A.
99.4
99.6
N.A.
90.8
46.6
52.7
46.6
N.A.
31.3
68
43.6
70.8
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
100
0
6.6
0
N.A.
20
13.3
0
0
P-Site Similarity:
100
6.6
100
100
N.A.
100
100
N.A.
100
20
20
0
N.A.
33.3
20
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
14
0
0
7
0
0
7
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
0
7
0
% C
% Asp:
0
7
0
0
7
0
0
0
7
7
0
0
14
0
0
% D
% Glu:
7
0
0
7
7
7
7
0
7
0
0
7
0
14
14
% E
% Phe:
0
0
0
0
40
0
14
0
0
0
14
7
0
14
0
% F
% Gly:
7
0
0
14
0
14
40
0
0
0
0
0
7
7
0
% G
% His:
0
7
0
0
14
0
0
7
0
0
7
7
7
0
0
% H
% Ile:
0
0
7
7
0
40
0
7
7
7
0
0
7
0
7
% I
% Lys:
0
7
14
0
0
0
14
7
7
14
0
14
0
0
7
% K
% Leu:
0
0
0
14
0
0
0
7
0
14
7
7
0
7
0
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
0
14
0
0
0
0
0
0
0
% N
% Pro:
7
54
7
0
7
14
7
0
54
7
0
40
0
0
40
% P
% Gln:
0
7
7
0
0
0
0
0
7
7
0
7
0
0
0
% Q
% Arg:
7
0
47
40
0
7
0
0
0
40
0
0
7
0
0
% R
% Ser:
47
7
7
0
0
20
7
40
7
0
0
7
14
40
7
% S
% Thr:
14
0
0
14
0
0
7
7
0
0
54
7
0
7
14
% T
% Val:
14
0
14
7
14
0
0
0
7
0
7
0
40
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
7
7
0
0
0
14
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _